December 9, 2021

The booster dose increases more than 12 times the antibody level

Published on 11/25/2021 5:46 PM / Updated on 11/25/2021 5:52 PM

(Credit: Ed Alves/CB/DA Press)

Study “Boost dose of inactivated vaccine increases neutralizing antibody and T-cell responses against SARS-CoV-2” (“Boost dose of inactivated vaccine increases neutralizing antibody and T-cell response against SARS-CoV-2”, free. translation), Posted on November 17th. In it, Chilean, American and Chinese researchers found that the stimulant dose of Corona It increased by more than 12 times the level of antibodies in those who had taken two doses of the immunizing agent for at least five months.

129 volunteers were deployed who received The first dose of CoronaVac From January to March 2021, the second with an interval of 28 days. Five months later, the volunteers took the booster dose. 77 volunteers demonstrated the ability to neutralize antibodies.

In adult volunteers aged 18 to 59 years, the neutralizing ability of the antibodies peaked four weeks after the booster dose. Compared to five months after the second dose, the number increased more than 18-fold. When compared to numbers two weeks after the second dose, levels recorded increased more than fourfold.

Within just four weeks after the second dose, the seropositivity in the group reached 100%. Usually, in immunization against Covid virus in two doses, every 28 days, the peak in neutralizing ability of antibodies is reached two weeks after the second dose.

In those over 60 years of age, which corresponds to 53.2% of volunteers, the researchers noted that after the booster dose, there was more than nine times growth in equivalent ability compared to what was analyzed five months after the second dose.