Nov 28, 2025
3 min read
Longer duration of hypothyroidism in pregnancy is associated with a higher risk
- Chronic maternal hypothyroidism and gestational hypothyroidism may be associated with an increased risk of autism spectrum disorder (ASD) in offspring.
- The association is dependent on Desents, with an increased risk of ASD and other related hypothyroidism.
- Adequate treatment may support thyroid hormone levels during pregnancy and support recommendations for cut-off hormone levels.
Adequately treated chronic hypothyroidism in pregnant women is not associated with autism spectrum disorder (ASD) in the offspring, but persistent hormonal imbalance during the trimester is associated with an increased risk of ASD, according to a retrospective study of Israeli births.
The role of the stomach tipu tipu in patonage - despite adequate treatment - is significantly related to Arrael in addition (95% HD + 05%).
However, the combination of chronic hypothyroidism and more than two arms was involved in children compared to children compared to daughters with normal thyroid function 1.41, 95% CI 1.61, 95% CI 1.61, 95% CI 1.61, 95% CI 1.61, 95% CI 1.61,
Longer periods of combined exposure to chronic hypothyroidism and pregnancy during pregnancy were correlated with a greater risk of ASD in offspring:
-Any three months of exposure: HR 1.35 (95% CI 1.02-2.44)
- Two quarters exposure: adjusted HR 2.04 (95% CI 1.20-6.19)
- triple exposure: Adjusted hours 2.87 (95% CI 1.10-9.94)
“Although causal claims are premature, these results are consistent with the hypothesis of monitoring and treating the thyroid gland to maintain euthyroidism.
Menashe told MedPage Today that the dose-response pattern is a new finding and a bit of a surprise.This highlights that "a true thyroid hormone imbalance during pregnancy and not a chronic disease is associated with ASD in the offspring."
The findings add to mounting data suggesting maternal thyroid dysfunction during pregnancy can affect fetal neurodevelopment.Although preliminary studies have recommended prenatal screening and treatment for thyroid imbalance, up to this point maternal medication use has been left out of the equation, Menasseh and co-authors noted.
Of all the maternal risks associated with the risk of ASD in offspring, maternal thyroid dysfunction during pregnancy "has received particular attention," the researchers said.
"Thermone Hourmone is important for owners of a neuron fetus, where the fetus is more reliant on Horneral taking the hormone through the placenta, especially in the first trimester," he explained.
The findings "open up new research pathways to the molecular mechanisms underpinning the link between abnormal levels of thyroid hormones and fetal neurodification," Menashe said.
"Given the prevalence of thyroid dysfunction in women of reproductive age and the availability of available treatments, elucidating the relationship between these conditions and ASD is of clinical importance," the researchers wrote.
A review study analyzed singleton births at Saran University in Israel between January 2011 and December 2011 and collected maternal identification data for maternal examination, maternal and child care, and ASD offspring.The mean age of diagnosis of Asd was 4.6 years.
Of the 51,296 women included in the study, 4,409 (8.6%) were diagnosed with abnormal thyroid function.Women with thyroid dysfunction had at least one thyroid function test performed in each trimester.
Of those with abnormal thyroid function, 1,161 had chronic hypothyroidism, 1,600 had gestational hypothyroidism, and 1,054 had acute hypothyroidism.One hundred women had chronic hyperthyroidism, 376 had gestational hyperthyroidism, and 15 women had both diseases.
The risk of ASD in the offspring of women with gestational hypothyroidism alone did not differ from the high-risk group with normal thyroid function.
Compared with euthyroid women, women with thyroid dysfunction were older, had higher rates of assisted reproductive technology and in vitro fertilization, and had higher rates of prenatal and perinatal conditions such as gestational diabetes, hypertension, caesarean section, and assisted delivery.
Although these deficits were corrected for the study, the researchers said in the journal Reminder Speakers that the relationship between mothers with low thyroid disease and their offspring may be disturbed.Other strengths of the study include the lack of data on levothyroxine treatment, iodine status, and your naterna antibody status, they agreed.
